Brain-compatible classrooms are brain-friendly places in which the teaching/learning process is based on how the brain functions and the mind learns. We will use brain science and cognitive science to examine and reshape how, where, what, and when we teach. Brain compatible classrooms are designed with challenging, creative, safe, enriched environments that balance direct instruction with hands-on authentic constructivist learning. Brain-friendly strategies include teaching for, of, with, and about thinking/reflection. Course curriculum includes ways to recognize the diverse conditions that confront learners and how to address specific learning needs of diverse, at-risk students, including those who are hard to reach.