Ann, Mary and Paul Twomey's third child, took a completely different route from the rest of her siblings. Much to her mothers pride, Ann joined the Sisters of St. Joseph. In joining the Sisters of St. Joseph, Ann took vows of chastity and poverty. During the famine Ann, along with the other sisters, did their best to minister to the poor and suffering; however, there was little they could do. Eventually, Ann contracted Typhus from one of the poor starving retches that came to the sister in search of food. Within a week, she was buried in the local church yard.