Eric Yixin Yang, M.D., Ph.D.
Associate Professo, Chair
Department of Biological Sciences
1 Kellogg Circle, Box 4050
Emporia State University
Emporia, KS 66801
Phone: 620-341-5608 (office)
Ph.D. in Molecular Biology, Microbiology and Biochemistry
Department of Microbiology
Program of Molecular Biology, Microbiology and Biochemistry
Southern Illinois University at Carbondale
Advisor: Dr. Douglas Fix
Medical Degree in Clinical Medicine
Dalian Medical University
Dalian City, Liaoning Province, China
M.S. in Computer Science
Department of Computer Science
Southern Illinois University at Carbondale
Advisor: Dr. Bidyut Gupta
MC 459/859 Bioinformatics, Emporia State University
GB 170 Honors Biology, Emporia State University
MC 316 Microbiology, Emporia State University
MC 317 Microbiology Laboratory, Emporia State University
MC 562 Pathogenic Microbiology, Emporia State University
MC 563 Pathogenic Microbiology Laboratory, Emporia State University
GB 141 Principles of Biology Laboratory, Emporia State University
Java Programming, Southern Illinois University
Research Presentation Awards won by Research Team
4/2016: Chris Alderman received the Great Plains Honors Council Boe Award for our research paper entitled “The in vitro and in vivo effects of MicroRNA-15a on human malignant melanoma and the newly discovered target gene of microRNA-15a” on the Great Plains Honors Council Conference in Siloam Springs, AR.
4/2016: the first place poster presentation award at graduate level at the 148th Annual Meeting of Kansas Academy of Science in April 1-2, 2016 in McPherson, KS.
12/2015: Undergraduate Student Travel Award for attending 2015 General Meeting of American Society for Cell Biology.
12/2015: Graduate Student Travel Award for attending 2015 General Meeting of American Society for Cell Biology.
05/2015: the third place award of Three Minute Thesis Talk at 2015 ESU Research and Creativity day
05/2015: Phi Kappa Phi Awards for best graduate abstracts at 2015 ESU Research and Creativity day
12/2014: Graduate Student Travel Award for attending 2014 General Meeting of American Society for Cell Biology.
05/2014: Phi Kappa Phi presentation abstract award on ESU Research and Creativity Day
04/2014: the first place of the oral presentation award at 146th Annual Meeting of Kansas Academy of Science.
01/2014: undergraduate student Ayoub Sehlaoui was selected to give platform oral presentation at K-INBRE Annual Symposium. Only eight out of more than 130 presentations were selected to give oral presentations.
04/2013: the first place of the oral presentation award at 145th Annual Meeting of Kansas Academy of Science.
12/2012: Undergraduate/Master’s Student Travel Award for attending 2012 General Meeting of American Society for Cell Biology.
03/2012: the third place of oral presentation at 144th Annual Meeting of the Kansas Academy of Science, Baldwin, Kansas
04/2011: the second place poster award at 143th Annual Meeting of the Kansas Academy of Science, Baldwin, Kansas
03/2010: the second place of the poster presentation award at142th Annual Meeting of the Kansas Academy of Science, Fort Hays, Kansas
03/2010: the third place of the poster presentation award at142th Annual Meeting of the Kansas Academy of Science, Fort Hays, Kansas
03/2010: the second place of the oral presentation award 142th Annual Meeting of the Kansas Academy of Science, Fort Hays, Kansas
01/2010: award of poster presentation; only 10 out of 100 posters received the awards. The 8th Annual K-INBRE Symposium. Kansas City, MO.
03/2009: the second place of the poster presentation award at 141th Annual Meeting of the Kansas Academy of Science, Topeka, Kansas
03/2009: the third place of the poster presentation award 141th Annual Meeting of the Kansas Academy of Science, Topeka, Kansas
03/2008: the first place of the poster presentation award at 140th Annual Meeting of the Kansas Academy of Science, Emporia, Kansas
Selected Peer-reviewed Publications:
- Yang, G., Yan, Y., Yang, Y. Vitamin C at high concentrations induces cytotoxicity in malignant melanoma but promotes tumor growth at low concentrations. Molecular Carcinogenesis (In press).
Hu C, Zhao Y, Yang Y (2016). Synergism of Dam, MutH, and MutS in methylation-directed mistmatch repair in Escherichia coli. Mutation Research (In press) DOI: 10.1016/j.mrfmmm.2016.12.002
Alderman C, Yang Y. (2016). The Anti-melanoma activity and oncogenic targets of hsa-miR-15a-5p. RNA and Disease. 2016; 3: e1450. doi: 10.14800/rd.1450
Alderman C, Sehlaoui, Xiao Z, Yang Y. (2016). MicroRNA-15a inhibits the growth and invasiveness of malignant melanoma and directly targets on CDCA4 gene. Tumor Biology. PMID: 27492455. DOI: 10.1007/s13277-016-5271-z
Yunqi Zhao, Ran Chen, Yun Wang, Wei Wang, Yixin Yang. (2016) In Vitro and In Vivo Efficacy Studies of Lavender angustifolia Essential Oil and Its Active Constituents on the Proliferation of Human Prostate Cancer. Integrative Cancer Therapies. pii: 1534735416645408. PMID:27151584
Li Z, Wang XP, Lin HP, Xu B, Zhao Q, Yang YX, Wang ZR (2015). Anti-tumor immunity elicited by cross-linking vaccine heat shock protein 72 and alpha-fetoprotein epitope peptide. Neoplasma. 2015;62(5):713-21. doi: 0.4149/neo_2015_085. PMID: 26278150
Wang, XP, Lin, HP, Xu, B, Fang, JG, Yang, YX (2014). Chaperoned Function of HSP72 in Hepatocellular Carcinomas. 2014 IEEE Workshop on Electronics, Computer and Applications
Wang X, Wang Q, Lin H, Sun L, Yang EY (2013). HSP72 and gp96 in gastroenterological cancers. Clin Chim Acta. Vol 417: 73-79. PMID: 23266770
Wang X, Wang Q, Lin H, Wang Y, Yang Y. (2013). Glycoprotein 96 and α-fetoprotein crossing-link complex elicited specific antitumor immunity. Cancer Biotherapy and Radiopharmaceuticals. Vol 28 (5):406-14. PMID: 23484810
Ma, X., Yang, Y., Wang, Y., An, G., and Lv, G. (2012) In vitro Study on the Effect of RNAi on the Expression of S100A4 and the Invasiveness of Osteosarcoma Cells. Journal of Dalian Medical University. Vol. 34, No. 1
Ma, X., Yang, Y., Wang, Y., Lv, G. (2010) Small Interfering RNA-Directed Knockdown of S100A4 Decreases Proliferation and Invasiveness of Osteosarcoma Cells. Cancer Letters 299: 171-181
Xiao Zhao-yang, Wang Shou-ping, Yang Yi-xin. (2010) Mechanism of the Preconditioning Protection against Anoxia-reoxygenation Injury of Neonatal Rat Cardiomyocytes. Journal of Anesthesiology 30:11.
Wolyniak M.J., Alvarez C.J., Chandrasekaran V., Grana T.M., Holgado A., Jones C.J., Morris R.W., Pereira A.L., Stamm J., Washington T.M., and Yang Y. (2010). Building Better Scientists Through Cross-disciplinary Collaboration in Synthetic Biology: A Meeting Report from the Genome Consortium for Active Teaching (GCAT) Workshop 2010. Cell Biology Education-Life Sciences Education 9(4):399-404.
Schrock J. R. and Yang, Y (2007). The Growing Problem of Plagiarism and the Correct Use of Science Citation. Biology Teaching 32, No.7
Guo Wei-jia, Miao Zhuang, Xiao Zhao-yang, Yang Yi-xin. (2007) Effects of Dexamethasone on Neuromuscular Blocking Efficiency of Atracurium. Journal of Dalian Medical University. Vol. 29, No. 2
Guo Wei-jia, Xiao Zhao-yang, Yang Yi-xin. (2007) The Effectiveness of Transdermal Fentanyl Combined with Clodine for Pain Control of Acute Herpes Zoster. Journal of Dalian Medical University. 29, No. 3
Gupta, S. Rahimi, and Y. Yang. (2007) A Novel Roll-back Mechanism for Performance Enhancement of Asynchronous Checkpointing and Recovery, Informatica, 31: 1-13
Gupta, B., Yang, Y., Rahimi, S., and Vemuri, A. (2006) A High-Performance Recovery Algorithm for Distributed Systems. ISCA 21st International Conference on Computers and Their Applications, March 23-25, 2006, Seattle, Washington, USA. Editor: J. Jackson, ISBN: 1-880843-58-7
Yang, Y. and D. Fix. (2006) Genetic Analysis of the Anti-mutagenic Effect of Genistein in Escherichia coli. Mutation Research. 600: 193- 206
Yang, Y. and D. Fix. (2001) Reduction of ENU-induced Transversion Mutations by the Isoflavone Genistein in Escherichia coli. Mutation Research. 8; 479(1-2):63-70.
Manuscripts Under Review:
Liu, C, Ni, Yiting, Chris Smith and Yang, Y. Zerumbone Inhibits the Growth and Metastasis of Malignant Melanoma through Inducing Apoptosis and Autophagy and Suppressing Cell Survival Signaling Pathways. (Under the second round of review with Molecular Carcinogenesis).
Yang, C., Qian, H., Yang, Y. MicroRNA 26a Inhibits Proliferation and Metastasis of Human Malignant Melanoma Cells and It Targets on MITF Gene. (Manuscript was submitted to Molecular Carcinogenesis, under review)
Zhao Y, Chen R, Yang Y (2016). The Anti-proliferative Activity of Rosmarinus officinalis Essential Oil on Human Prostate Cancer in Mouse Xenograft Model. (manuscript submitted to BioMed Research International)
Yang, Y., Wang, X. Protective Effect of Mercuric Chloride at Sub-lethal Concentrations in Escherichia coli against Cytotoxicity of N-ethyl-N-nitrosourea and Ultraviolet Light. (Manuscript was submitted to Mutation Research)
- Ma, Y., Zhao, Y. and Yang, Y. Characterization of the Antimicrobial and Anti-tumor Substance Produced by Brebacillus laterosporus Isolated from the Rocky Mountains National Park. (Manuscript was submitted to Microbiological Research)
Targeted Nano-medicine for Prostate Cancer Treatment. Chapter 4 of Recent Advances in Prostate Cancer published by Avis Science.
Malignant melanoma is currently the leading cause of death from cutaneous malignancies, and it is estimated that one out of 61 persons in United States will develop malignant melanoma in his or her lifetime. The incidence of melanoma has increased five-fold during the past three decades, and is rising faster than any other cancer in men and second only to lung cancer in women. Metastasized melanoma is extremely aggressive, often fatal, and refractory to current therapies. It has a very poor prognosis: the median survival rate is 6 months, and the 5-year survival rate is less than 5-15%. Therefore, there is pressing need to seek powerful chemotherapeutic agent to cure malignant melanoma.
My lab has been conducting several lines of research aiming to advance the understanding of melanoma biology and therapeutics. (1) My lab is currently studying the effects and working mechanisms of supplementary antioxidants like Vitamin C, β-carotene and co-enzyme Q10 on the growth and metastasis of human malignant melanoma and their effect on the therapeutic efficacy of FDA approved anti-melanoma BRAF and MEK inhibitors. (2) Also, my research group has been working on developing cocktail therapy regimen combining BRAF inhibitors with heat shock protein inhibitors and autophagy inhibitors to overcome the drug resistance in human malignant melanoma cells. (3) In addition, we also investigate the biological functions of microRNAs (miR-15a, miR-26a, let-7a, etc.) in growth, motility, invasiveness and apoptosis of melanoma cells, aiming to develop microRNA-based therapy against melanoma. We are currently developing a novel CRISP-Cas9 system for increasing the expressions of tumor suppressor microRNAs. (4) We are currently defining the differential activation patterns of p53 network in melanoma cell with different genetic context, with the goal of identifying the therapy targets for restoring the deregulated p53 network in cancers. (5) My lab screens and examines the pharmacological effects of a number of standard preparation of plant extracts and individual constituents of the extract on malignant melanoma. We elucidate the anti-melanoma mechanisms by examining the differential gene expression profiles of melanoma cells in response to phytochemicals. We also identify the genes and signaling pathways that phytochemicals target to exert the anti-melanoma effects by gene knockout through RNA interference.
In addition, our group has other three ongoing projects that my graduate students are currently working on: (1) Interactive effects between dam (methylation of GATC sites) deficiency mutation and the mutations of mutD, mutH, mutL, or mutS (genes required for methyl-directed mismatch repair). (2) Effect of mercuric compound at sublethal concentrations on the survivability of bacterial cells challenged by genotoxic agents (3) Characterizing a novel antimicrobial and anti-tumor agent produced by a strain of Brevibacillus laterosporus, a spore-former isolated from Rocky Mountain soil sample.
Due to my background in both molecular genetics and computer science, I am also interested in giving solutions to the mathematical or computing algorithm problem using bacteria cells, taking advantage of directionality of genes. My lab is working on designing innovative genetic circuits to facilitate topological search and solve Hamiltonian path problem.
Andrew Xiao, M.D., Ph.D., currently a Professor and Chair of Department of Emergency ICU at the 2nd Affiliated Hospital of Dalian Medical University.
Yunqi “Chloe” Zhao, Ph.D., currently an Associate Professor at School of Pharmacy of Kunming Medical University
- Harold Durst Graduate Research Award of 2008
- The first place presentation award of 140th Annual Meeting of Kansas Academy of Science in 2008
- The second place presentation award of 141th Annual Meeting of Kansas Academy of Science in 2009
- The best poster presentation award of 2009 Emporia State University Research and Creativity Forum
Chang, Liu, Ph.D., currently a postdoctorate fellow at Yale University.
- Travel Award of American Society of Cell Biology
- The second place and third place of poster presentation award at 142nd Annual Meeting of KAS in 2010
- The second place of poster presentation award at 143rd Annual Meeting of KAS in 2011
- 2010 Biology Graduate Student Scholarship
Brandy Hanson, B.S., currently a M.D. student at Kansas City University of Medicine and Biosciences)
David Nasrazadani, BMB undergraduate student. David’s research work received the poster award at 8th Kansas IDeA Network of Biomedical Research (K-INBRE) Symposium in 2010
Christian Smith, BMB undergraduate student
Yiliu Liu, BMB undergraduate student
Anthony Westby, Biology undergraduate student
Tim Moser, Biology undergraduate