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Department of Biological Sciences


Eric Yixin Yang, M.D., Ph.D.

 picture of Yang

Associate Professor

Department of Biological Sciences

1200 Commercial Street

Emporia State University

Emporia, KS 66801

Phone: 620-341-5610 (office)

Email: yyang@emporia.edu

Education

Ph.D. in Molecular Biology, Microbiology and Biochemistry, 2003
Department of Microbiology
Program of Molecular Biology, Microbiology and Biochemistry
Southern Illinois University at Carbondale
Advisor: Dr. Douglas Fix

Medical Degree in Clinical Medicine, 1996
Dalian Medical University
Dalian City, Liaoning Province, China

M.S. in Computer Science, 2005
Department of Computer Science
Southern Illinois University at Carbondale
Advisor: Dr. Bidyut Gupta

Courses Taught

Bioinformatics MC 859/459, Emporia State University
Honors Biology GB 171, Emporia State University
Microbiology MC316, Emporia State University
Microbiology Laboratory MC317, Emporia State University
Pathogenic Microbiology MC562, Emporia State University
Pathogenic Microbiology Laboratory MC563, Emporia State University
Principles of Biology Laboratory GB141, Emporia State University
Java Programming, Southern Illinois University

Professional Membership

Sigma Xi the Scientific Research Society
American Association for the Advancement of Science (AAAS)
American Society of Microbiology (ASM)
American Society of Cell Biology (ASCB)
Phi Kappa Phi Honor Society

Selected Presentations (seminars-posters-invited speaker)

  • 12/2010: poster, “Anti-Proliferative and Anti-invasive Effects of Oleanic Acid in Human Malignant Melanoma Cells”. 50th Annual Meeting of the American Society for Cell Biology, Philadelphia, PA.
  • 12/2010: poster, “Molecular Mechanisms of Inhibitory Effect of Zerumbone on Human Malignant Melanoma Cells.” 50th Annual Meeting of the American Society for Cell Biology, Philadelphia, PA.
  • 03/2010: poster, “Zerumbone and Luteolin, Two Bioactive Herbal Extraction, Induce Cell cycle Arrest and Apoptosis of Human Malignant Melanoma Cells. 142th Annual Meeting of the Kansas Academy of Science, Fort Hays, Kansas (the second place award of poster presentation)
  • 03/2010: poster, “Potential Therapeutic Effects of Cinnamon Leaf Oil and Its Constituents on Human Malignant Melanoma Cell”. 142th Annual Meeting of the Kansas Academy of Science, Fort Hays, Kansas (the third place award of poster presentation)
  • 03/2010: oral, “The Anti-proliferation and Cell Cycle G2/M Phase Arrest of Human Melanoma Cells Caused by Curcumin”. 142th Annual Meeting of the Kansas Academy of Science, Fort Hays, Kansas (the second place award of the oral presentation).
  • 03/2010: poster, “Using Microarray Analysis to Elucidate the Protective Effect of Mercuric Compound at Sub-lethal Concentrations Against the Bactericidal Effect of Ultraviolet Light on Escherichia coli Cells.” 142th Annual Meeting of the Kansas Academy of Science, Fort Hays, Kansas    
  • 01/2010: poster, “The Effect of Curcumin on the Growth of Human Malignant Melamoma Cells.” The 8th Annual K-INBRE Symposium. Kansas City, MO. (award of poster presentation, 9 out of about 100 posters received the awards)
  • 03/2009: poster,Gene Expression Profile of Malignant Melanoma Cells in Response to the Treatment By Ginkgo Biloba Leaf Extract”. 141th Annual Meeting of the Kansas Academy of Science, Topeka, Kansas (the second place award of the poster presentation)    
  • 03/2009: poster,Effect of Mercuric Compound at Sublethal Concentrations on the
  • Survivability of Bacterial Cells Challenged by Ultraviolet Light or N-Ethyl-
  • N-Nitrosourea”. 141th Annual Meeting of the Kansas Academy of Science, Topeka, Kansas (the third place award of the poster presentation)     
  • 03/2009: Poster, “The toxicity of Luria-Bertani Medium on Certain Escherichia coli Strains”. 141st Annual Meeting of Kansas Academy of Science at Topeka, Kansas
  • 12/2008: Poster, “Microarray Analysis of the Effect of Ginkgo Biloba Leaf Extract on the Proliferation of Malignant Melanoma cells”. 48th General Meeting of American Society for Cell Biology (ASCB), San Francisco, CA
  • 06/2008: Poster, “Characterization of a Novel Antimicrobial and Antitumor Agent Produced by Brevibacillus laterosporus.” 108th General Meeting of American Society for Microbiology (ASM), Boston, MA
  • 03/2008: Poster, “Characterization of Antimicrobial and Antitumor Agents Produced by Isolates of Soil from Rocky Mountain National Park”. 140th Annual Meeting of the Kansas Academy of Science, Emporia, Kansas (the first place award of the poster presentation)     
  • 03/2008: Poster, “The Effect of Ginkgo biloba Leaf Extract and Its Active Constituents on the Proliferation of Malignant Melanoma Cells”. 140th Annual Meeting of the Kansas Academy of Science, Emporia, Kansas
  • 11/2004: Poster, "The Isoflavone Genistein Reduces SOS-Dependent Mutation in Escherichia coli", ASM Conference on DNA Repair and Mutagenesis: From Molecular Structure to Biological Consequences, Southampton, Bermuda
  • 10/2003: Invited speaker, "Reduction of Transversion Mutations by the Isoflavone Genistein in Escherichia coli", Fall 2003 Seminar Series, Program of Molecular Biology, Microbiology and Biochemistry, Southern Illinois University at Carbondale
  • 05/2003: Invited speaker, "The Application of Embryonics and Immunotronics in Fault Tolerance", Semester Seminar, Department of Computer Sciences, Southern Illinois University at Carbondale
  • 02/2003: Invited speaker, "Soybean and Human Health", invited by Civic Center of Carbondale as part of Health Awareness Program.
  • 05/2002: Poster, "Effect of Isoflavone Genistein on Mutagenesis induced by ENU and UV in Escherichia coli", 104th General Meeting of American Society of Microbiology, New Orleans, LA
  • 05/2000: Poster, "Alleviation of ENU-induced Mutagenesis by genistein", 2nd Annual Midwest DNA Repair Symposium, University of Louisville


Selected Refereed Publications:

  • Ma, X., Yang, Y., Lv, G. (2010) Small Interfering RNA-Directed Knockdown of S100A4 Decreases Proliferation and Invasiveness of Osteosarcoma Cells. Cancer Letters Vol. 299: 171-181
  • Wolyniak J. Michael, Alvarez J. Consuelo J, Yang Yixin, etc. (2010) Building Better Scientist Through Cross-disciplinary Collaboration in Synthetic  Biology: A Meeting Report From The Genome Consortium for Active Teaching (GCAT) Workshop 2010. CBE—Life Sciences Education 9(4):399-404.
  • Xiao Zhao-yang, Wang Shou-ping, Yang Yi-xin. (2010) Mechanism of the Preconditioning Protection Against Anoxia-reoxygenation Injury of Neonatal Rat Cardiomyocytes. China Journal of Anesthesiology (in press) (corresponding author)
  • Liu, C and Yang, Y. The Effect of Zerumbone on the Proliferation and Invasiveness of Human Malignant Melanoma Cells (submitted to Molecular Cancer Research) (corresponding author).
  • Xiao, Z., Wang, S. and Yang, Y. Temporal Changes of Proenkephalin and Prodynorphin mRNA and Their Derived Peptides in the Kainic Acid Induced Epileptic Rat. (submitted to Journal of Biomedical Science) (corresponding author).
  • Zhao, Y. and Yang, Y. Microarray Analysis of the Anti-melanoma Effects of Kaempferol. (submitted to Cancer Letters) (corresponding author)
  • Zhao, Y and Yang, Y. The Gene Expression Profile of Human Malignant Melanoma Cells Treated by Ginkgo Biloba Leaf Extract  (submitted to Phytomedicine) (corresponding author)
  • Zhao, Y and Yang, Y. Characterization of the Antimicrobial and Anti-tumor Substance Produced by Brebacillus laterosporus Isolated from Rocky Mountain. (in preparation) (corresponding author)
  • Wang, X and Yang, Y. Molecular Response to Mercuric Chloride in Escherichia coli Challenged by Genotoxic Agents. (submitted to Journal of Bacteriology) (corresponding author)
  • Schrock J. R. and Yang, Y (2007). The Growing Problem of Plagiarism and the Correct Use of Science Citation. Biology Teaching Vol. 32, No.7
  • Yang, Y. and D. Fix. (2006) Genetic Analysis of the Anti-mutagenic Effect of Genistein in Escherichia coli. Mutat Res. 600: 193- 206
  • Gupta, B., Yang, Y., Rahimi, S., and Vemuri, A. (2006) A High-Performance Recovery Algorithm for Distributed Systems. ISCA 21st International Conference on Computers and Their Applications, March 23-25, 2006, Seattle, Washington, USA. Editor: J. Jackson, ISBN:  1-880843-58-7
  • B. Gupta, S. Rahimi, and Y. Yang. (2007) A Novel Roll-back Mechanism for Performance Enhancement of Asynchronous Checkpointing and Recovery, Informatica, 31: 1-13
  • Yang, Y. and D. Fix. (2001) Reduction of ENU-induced Transversion Mutations by the Isoflavone Genistein in Escherichia coli. Mutat Res. 8; 479(1-2):63-70.

 


Research Interests

Phytochemicals are natural chemicals extracted from plants. Phytochemicals has drawn considerable attention due to their extensive biological activities involved in cancer prevention and treatment. Phytochemicals has demonstrated preferential induction of cell cycle arrest and apoptosis in tumor cell lines. In addition, phytochemicals modulate the expression of genes involved in tumor behavior and malignant transformation.

 

Malignant melanoma is currently the leading cause of death from cutaneous malignancies, and it is estimated that one out of 63 persons in United States will develop malignant melanoma in his or her lifetime. The incidence of melanoma has increased five-fold during the past three decades, and is rising faster than any other cancer in men and second only to lung cancer in women. Metastasized melanoma is extremely aggressive, often fatal, and refractory to current therapies. It has a very poor prognosis: the median survival rate is 6 months, and the 5-year survival rate is less than 5-15%. Therefore, there is pressing need to seek powerful chemotherapeutic agent to cure malignant melanoma.

My lab screens and examines the pharmacological effects of a number of standard preparation of plant extracts and individual constituents of the extract on malignant melanoma. We explore the numerous bioactivities of phytochemcials on melanoma cells: cytotoxicity, proliferation inhibition, apoptosis induction and cell cycle progression arrest, reduction in cell motility and invasiveness, etc. We elucidate the anti-melanoma mechanism by examining the differential gene expression profile of melanoma cells in response to phytochemicals. We also identify the genes and pathways that phytochemicals may target on to exert the anti-melanoma effects by gene knockout through RNA interference. In addition, we are investigating the relationship between structure of phytochemicals and pharmacological effect, especially the apoptosis induction and cell cycle perturbation. The goal of our research is to contribute to the design of viable novel targeted therapy to treat invasive melanoma.

 

In addition, our group has other three ongoing projects that my graduate students are currently working on: (1) Interactive effects between dam (methylation of GATC sites) deficiency mutation and the mutations of mutD, mutH, mutL, or mutS (genes required for methyl-directed mismatch repair). (2) Effect of mercuric compound at sublethal concentrations on the survivability of bacterial cells challenged by genotoxic agents (3) Characterizing a novel antimicrobial and anti-tumor agent produced by a strain of Brevibacillus laterosporus, a spore-former isolated from Rocky Mountain soil sample.

 

Due to my background in both molecular genetics and computer science, I am also interested in giving solutions to the mathematical or computing algorithm problem using bacteria cells, taking advantage of directionality of genes. My lab is working on designing innovative genetic circuits to facilitate topological search and solve Hamiltonian path problem.

 


Research team:

Andrew Xiao, M.D., Ph.D., currently an Associate Professor at Department of Anesthesiology at China 4th Military Medical University. He recently received a major research grant from National Natural Science Foundation of China.

 Zhaoyang Xiao 1Zhaoyang Xiao 2

Yunqi “Chloe” Zhao, M.S., currently a Ph.D. candidate at Department of Pharmaceutical Chemistry at University of Kansas (a top ten Pharmaceutical Science Ph.D. Program of the United States). Chloe received the following awards as result of her research work at my lab:

  • Harold Durst Graduate Research Award of 2008
  • The first place presentation award of 140th Annual Meeting of Kansas Academy of Science in 2008
  • The second place presentation award of 141th Annual Meeting of Kansas Academy of Science in 2009
  • The best poster presentation award of 2009 Emporia State University Research and Creativity Forum

Yunqi Zhao   Chloe Zhao

 

Xiaobo “Linda” Wang, M.S. candidate. Linda received following awards as result of her work at my lab. Linda will join Pharmacology Ph.D. and MBA combined program in Pennsylvania State University in August 2011.

  • The second place of oral presentation award at 142nd Annual Meeting of KAS in 2010
  • The third place of poster presentation award at 141st Annual Meeting of KAS in 2009
  • 2010 Laurence C. Boylan Scholar Award
  • 2009 Biology Graduate Student Scholarship

Xiaobo WangLinda Wang

Chang, Liu, M.S. candidate. Chang received M.D. from China Medical University. Chang received the following awards as result of her research work at my lab. Chang received admission and full financial support from ten prestigious Ph.D. programs including Pharmacology programs in University of Colorado at Boulder (ranked No. 30), University of Minnesota (ranked No. 32), University of Indiana at Bloomington (ranked No. 34), University of Virginia (ranked No. 46), Purdue University (ranked No. 56), University of Iowa (ranked No. 56) and M.D. Anderson Cancer Center (ranked No.1 in cancer research).

  • Travel Award of American Society of Cell Biology
  • The second place and third place of poster presentation award at 142nd Annual Meeting of KAS in 2010
  • The second place of poster presentation award at 143rd Annual Meeting of KAS in 2011
  • 2010 Biology Graduate Student Scholarship

Chang Liu 1Chang Liu 2

 

Brandy Hanson, B.S., currently a M.D. student at Kansas City University of Medicine and Biosciences)

David Nasrazadani, BMB undergraduate student. David’s research work received the poster award at 8th Kansas IDeA Network of Biomedical Research (K-INBRE) Symposium in 2010

Christian Smith, BMB undergraduate student

Yiliu Liu, BMB undergraduate student

Anthony Westby, Biology undergraduate student

Tim Moser, Biology undergraduate

David 1David 2Chris SmithAnthony Wesby